Get Animal Models in Toxicology PDF

By Shayne C. Gad

ISBN-10: 0824754077

ISBN-13: 9780824754075

Even though i've got but to learn the publication in its entirety, i've got skimmed via numerous chapters & i locate that a lot of the concepts seem to be written in redundancy. might be i've got excessive expectancies, yet probably innovations which are played within the similar demeanour among species should be consolidated and referenced. the data for real toxicology within the a number of species is especially beneficial.

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Comparison of in vitro drug metabolism by lung, liver, and kidney of several common laboratory species. Drug Metab. Dispos. 3, 259–265. Mandel, H. (1972). Pathways of drug biotransformation: Biochemical conjugation. In Fundamentals of drug metabolism and drug disposition, eds. B. LaDu, H. Mandel, and E. Way, 149–186. Baltimore: Williams & Wilkins. Mannering, G. (1972). Microsomal enzyme systems which catalyze drugs. In Fundamentals of drug metabolism and drug disposition, eds. B. LaDu, H. Mandel, and E.

Dispos. 11, 275–276. , and Vainio, H. (1973). Interspecies variations in small intestinal and hepatic drug hydroxylation and glucuronidation. Acta Pharmacol. Toxicol. 33, 57–64. , and Vainio, H. (1976). Effect of administration route on DDT acute toxicity and on drug biotransformation in various rodents. Arch. Environ. Contam. Toxicol. 4, 201–216. , and Kalant, H. (1972). The metabolism of ethanol and its metabolic effects. Pharmacol. Rev. 24, 67–157. , and Millburn, P. (1977). Comparative aspects of the biosynthesis and excretion of xenobiotic conjugates by non-primate mammals.

The appropriate choice of a strain of mice for a particular toxicity study should consider the specific objectives of the study and the specific characteristics of candidate strains that might assist or hinder in achieving those study objectives. One difference among strains is in the normal body weights of various strains at different ages. 4. 4. The CF-I strain has been reported to be highly resistant to mouse typhoid and to be relatively resistant to salmonellosis (Hill 1981). Nude or athymic strains of mice are more sensitive to tumor development than heterozygous strains.

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Animal Models in Toxicology by Shayne C. Gad

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