By Jill P. G. Urban, Robert J. Wilkins (auth.), Seisuke Tanaka M.D., Chiaki Hamanishi M.D. (eds.)
Basic learn on osteoarthritis has been conducted as a rule from the his tological and biochemical features of the degenerating chondrocytes, collagen fibers, and matrix proteoglycans. Undue mechanical pressure has been proven to be the relevant think about the initiation of osteoarthritis. even supposing the precise approach through which mechanical tension results in the complete destruction of cartilage tissue continues to be uncertain, a number of new examine tools have enabled us to realize a deeper realizing of the method of degeneration. In October 1997, we prepared a global symposium titled "Ad vances in Osteoarthritis" in Kobe, with the most themes being up-to-date re seek, analysis, and remedy of osteoarthritis. The court cases of the symposium are awarded the following in 5 sections: (1) Mechanical pressure and reactions of chondrocytes, equivalent to intracellular ion adjustments, alterations within the cytoskeleton, intracellular messenger platforms, unencumber of gasoline mediators, and adjustments in electromechanical homes of cartilage; (2) practical prognosis of osteoarthritis via MR imaging, and utilizing calpain and collagenase III as new cartilage markers; (3) remedy with a promising easy washout procedure and IL-1RA and MMP antagonists; (4) Cartilage fix by way of new grafting tech niques; and (5) difficulties following overall joint substitute. We basically desire that the complex wisdom supplied during this quantity of lawsuits should be necessary to our readers.
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Parkkinen et al. processing of the core protein was involved, including GAG assembly and sulfation in the endoplasmic reticulum and the Golgi apparatus, rather than enhanced transcription. 5-Hz) cycle, and only in the superficial zone . The superficial zone aside of the loading head is mainly subject to stretching, suggesting that tensile forces are also an important stimulus for PG synthesis. Influences of Hydrostatic Pressure on Matrix Synthesis Hydrostatic pressure within articular cartilage is raised during each dynamic loading event of a joint.
J Lab Clin Med 127:540-544 11. Sumpio BE, Banes AJ, Levin LG, et al (1987) Mechanical stress stimulates aortic endothelial cells to proliferate. J Vasc Surg 6:252-256 12. Nishioka S, Fukuda K, Tanaka S (1993) Cyclic stretch increases alkaline phosphatase activity of osteoblast-like cells: a role for prostaglandin E 2• Bone Miner 21:141-150 13. Fukuda K, Ohtani K, Tanaka S, et al (1993) Keratan sulfate inhibits its release in rabbit chondrocyte. Connect Tissue Res 30:75-83 14. Fukuda K, Matsumura F, Tanaka S (1993) Histamine H2 receptor mediates keratan sulfate secretion in rabbit chondrocytes: role of cAMP.
New, unknown genes might be involved, stressing the importance of the current methods used in molecular biology to aid us in our search for specific genes affected by the pressure. Acknowledgments. The skillful and efficient technical assistance of Mrs. Elma Sorsa and Ms. Eija Antikainen is gratefully acknowledged. This work was financially supported by grants from the University of Kuopio, the North Savo Fund of the Finnish Cultural Foundation, the Finnish Cultural Foundation, the Academy of Finland, the Sigrid Juselius Foundation, and the Finnish Research Council for Physical Education and Sports, Ministry of Education.
Advances in Osteoarthritis by Jill P. G. Urban, Robert J. Wilkins (auth.), Seisuke Tanaka M.D., Chiaki Hamanishi M.D. (eds.)