By Keith Green (auth.), Keith Green, Henry F. Edelhauser, Robert B. Hackett, David S. Hull, David E. Potter, Ramesh C. Tripathi (eds.)
This quantity represents the court cases of the 5th Congress of the foreign Society of Ocular Toxicology (ISOT), which was once held on the Grove Park resort and lodge in Asheville, North Carolina, October 13-17, 1996. we're extremely joyful to give this quantity to the ophthalmic group, in particular people with an important curiosity in ocular toxicol ogy. The 5th Congress was once constructed round topics in terms of ocular drug metabolism, the ocular pathophysiological results of nitric oxide, govt matters in terms of using replacement tools for toxicity checking out, and a workshop that encompassed comparisons of either in vitro as opposed to in vivo types in addition to varied animal types. the end result of this congress, embodied during this quantity, is a contribution to the methodologies at the moment hired or less than improvement and to varied drug or actual results on varied ocular tissues. whereas the focal point of this lawsuits is on ocular results of substances or different fabrics, a few of the contributions care for issues that experience a wider curiosity. The workshop about the use of other version structures and the alternative of the easiest animal version for drug trying out covers a variety of pursuits that ex has a tendency some distance past particular ocular results. this can be very true within the quarter of different equipment and within the number of the easiest animal version for exam of alternative sickness entities.
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Additional resources for Advances in Ocular Toxicology
Protein-Thiol Mixed Disulfides in Human Cataracts In humans, the degrees of nuclear opacity and nuclear pigmentation are in proportion to the amount of PSSG and PSSC. Additionally, in mature nuclear opacity a 3rd protein-thiol mixed disulfide species, y-glutamyl-cysteine-S-S-protein is also found. 37 When human donor lenses 25 are used for Hp2-cataract induction in vitro, both PSSG and PSSC are profoundly increased (Figure 8). S. l. The Hypothesis Based on the above findings, we have proposed that protein-thiol mixed disulfide formation may playa critical role in cataractogenesis.
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Advances in Ocular Toxicology by Keith Green (auth.), Keith Green, Henry F. Edelhauser, Robert B. Hackett, David S. Hull, David E. Potter, Ramesh C. Tripathi (eds.)