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By Keith Green (auth.), Keith Green, Henry F. Edelhauser, Robert B. Hackett, David S. Hull, David E. Potter, Ramesh C. Tripathi (eds.)

ISBN-10: 146137720X

ISBN-13: 9781461377207

ISBN-10: 1461559375

ISBN-13: 9781461559375

This quantity represents the court cases of the 5th Congress of the foreign Society of Ocular Toxicology (ISOT), which was once held on the Grove Park resort and lodge in Asheville, North Carolina, October 13-17, 1996. we're extremely joyful to give this quantity to the ophthalmic group, in particular people with an important curiosity in ocular toxicol­ ogy. The 5th Congress was once constructed round topics in terms of ocular drug metabolism, the ocular pathophysiological results of nitric oxide, govt matters in terms of using replacement tools for toxicity checking out, and a workshop that encompassed comparisons of either in vitro as opposed to in vivo types in addition to varied animal types. the end result of this congress, embodied during this quantity, is a contribution to the methodologies at the moment hired or less than improvement and to varied drug or actual results on varied ocular tissues. whereas the focal point of this lawsuits is on ocular results of substances or different fabrics, a few of the contributions care for issues that experience a wider curiosity. The workshop about the use of other version structures and the alternative of the easiest animal version for drug trying out covers a variety of pursuits that ex­ has a tendency some distance past particular ocular results. this can be very true within the quarter of different equipment and within the number of the easiest animal version for exam of alternative sickness entities.

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Protein-Thiol Mixed Disulfides in Human Cataracts In humans, the degrees of nuclear opacity and nuclear pigmentation are in proportion to the amount of PSSG and PSSC. Additionally, in mature nuclear opacity a 3rd protein-thiol mixed disulfide species, y-glutamyl-cysteine-S-S-protein is also found. 37 When human donor lenses 25 are used for Hp2-cataract induction in vitro, both PSSG and PSSC are profoundly increased (Figure 8). S. l. The Hypothesis Based on the above findings, we have proposed that protein-thiol mixed disulfide formation may playa critical role in cataractogenesis.

A aS €l 3 a 00 a a '-' 00 a a a 2 a oar§! a cB a :r: Vl a aBC{) a 0 00 1 0 10 20 30 40 50 60 AGE (years) 70 80 90 Figure 5. Free GSH levels in normal human lenses as a function of age. 0005. yrs may be associated with a physiological function of PSSG in the lens while the latestage elevation is mostly pathological. It is also speculated that an age-dependent decrease in free GSH, in particular in older lenses, may contribute to the accumulation of PSSG in the same lenses (Figure 5). The effect of age on PSSG and PSSC in cortical and nuclear regions of the lens and the WS and WI protein fractions are summarized in Tables 4 and 5 respectively.

J Invest Dennatol 1994; 104:1-5. 118. Capdevila J, Gil L, Orellana M, Marnett LJ, Mason JI, Yadagiri P, Falck JR. Inhibitors of cytochrome P450 dependent arachidonic acid metabolism. Arch Biochem Biophys 1988; 261 :257-263. 119. Testa B, Jenner P. Inhibitors of cytochrome P4S0s and their mechanism of action. Drug Metab Rev 1981; 12:1-117. 120. Maines MD, Kappas A. Metals as regulators of heme metabolism. Science 1977; 198: 1215-1221. 20 M. L. Schwartzman 121. Maines MD, Kappas A. Studies on the mechanism of induction of heme oxygenase by cobalt and other metal ions.

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Advances in Ocular Toxicology by Keith Green (auth.), Keith Green, Henry F. Edelhauser, Robert B. Hackett, David S. Hull, David E. Potter, Ramesh C. Tripathi (eds.)

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